a tool for identifying drug-targetable redox-active disulphides

Major urinary protein 4

Intramolecular

Cysteine 80 and cysteine 173

A redox-regulated disulphide may form within Major urinary protein 4 between cysteines 80 and 173 (64 and 157 respectively in this structure).

Details

Redox score ?

85

PDB code

Structure name

major mouse urinary protein iv complexed with 2-sec-butyl-4,5- dihydrothiazole

Structure deposition date

2009-10-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

49

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

80

Residue number B

173

Peptide name

Major urinary protein 4

Ligandability

Cysteine 80 of Major urinary protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Major urinary protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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